Publications Publications

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2020     back to top


68. Pd-catalyzed imine-directed intramolecular CN bond formation through C(sp3)H activation: An efficient approach to multisubstituted pyrroles.

        Ting Yu, Qiang Zhu* and Shuang Luo* Tetrahedron Lett., 2020, 61, 151887-151891. <Link>



2019     back to top


67. Enantioselective Synthesis of 2‐Oxindole Spirofused Lactones and Lactams by Heck/Carbonylative Cylization Sequences: Method Development and Applications.

        Huaanzi Hu, Fan Teng, Jian Liu, Weiming Hu, Shuang Luo* and Qiang Zhu* Angew. Chem. Int. Ed., 2019, 58, 9225-9229. <Link>



66. Pd-Catalyzed C(sp2)–H Imidoylative Annulation: A General Approach To Construct Dibenzoox(di)azepines.

        Weiming Hu, Fan Teng Huaanzi Hu, Shuang Luo* and Qiang Zhu* J. Org. Chem., 2019, 84, 6524-6535. <Link>



65. Selective C−H or N−H Imidoylative Annulation of 2-(2-Isocyanophenyl)-1H-indoles Leading to Diverse Indole-fused Scaffolds.

        Fan Teng, Weiming Hu,  Huaanzi Hu, Shuang Luo* and Qiang Zhu* Adv. Synth. Catal., 2019, 361, 1414-1418. <Link>



2018     back to top


64. Copper-Catalyzed Bromodifluoroacetylation of Alkenes with Ethyl Bromodifluoroacetate.

        Dengke Li*, Tingting Mao, Jinbo Huang and Qiang Zhu* J. Org. Chem., 2018, 83, 10445-10452. <Link>



63. Cascade double isocyanide insertion and C–N coupling of 2-iodo-2′-isocyano-1,1′-biphenyls .

        Hongwei Sun, Shi Tang, Dengke Li, Yali Zhou, Jinbo Huang* and Qiang Zhu* Org. Biomol. Chem., 2018, 16, 3893-3896 . <Link>



62. PhI(OAc)2-mediated dearomative C–N coupling: facile construction of the spiro[indoline-3,2′-pyrrolidine] skeleton.

        Yali Zhou, Dengke Li, Hongwei Sun, Jinbo Huang* and Qiang Zhu* Org. Biomol. Chem., 2018, 16, 2039-2042. <Link>



61. Pd-Catalyzed Divergent C(sp2)–H Activation/Cycloimidoylation of 2-Isocyano-2,3-diarylpropanoates.

        Shi Tang, Sheng-Wen Yang, Hongwei Sun, Yali Zhou, Juan Li* and Qiang Zhu* Org. Lett., 2018, 20, 1832-1836. <Link>


60. Enantioselective Synthesis of Planar Chiral Pyridoferrocenes via Palladium-Catalyzed Imidoylative Cyclization Reactions.

        Shuang Luo*, Zhuang Xiong, Yongzhi Lu and Qiang Zhu* Org. Lett., 2018, 20, 1837-1840. <Link>


59. Stirring-controlled mono or double aminocarbonylation of 1,3-bis(2-iodoaryl)propan-2-amines.

       Huaanzi Hu, Zeqiang Xie, Shuang Luo* and Qiang Zhu* Tetrahedron Lett., 2018, 59, 1034-1037. <Link>



2017     back to top


58. Palladium-Catalyzed Imidoylative Cyclization of Tryptophan-Derived Isocyanides: Access to β-Carbolines.

       Shi Tang, Jian Wang, Zhuang Xiong, Zeqiang Xie, Dengke Li, Jinbo Huang* and Qiang Zhu* Org. Lett., 2017, 19, 5577-5580. <Link>



57. Palladium-catalyzed C(sp2)–H aminoimidoylation of isocyano-containing arenes: synthesis of amino substituted N-heterocycles.

       Zhuang Xiong, Jian Wang, Yanbo Wang, Shuang Luo* and Qiang Zhu* Org. Chem. Front., 2017, 4, 1768-1771. <Link>



56. Palladium-Catalyzed Enantioselective C(sp2)–H Imidoylation by Desymmetrization.

       Jian Wang, De-Wei Gao, Jinbo Huang, Shi Tang, Zhuang Xiong, Huaanzi Hu, Shu-Li You* and Qiang Zhu* ACS Catal., 2017, 7, 3832-3836. <Link>



55. Denitrogenative Imidoyl Radical Cyclization: Synthesis of 2-Substituted Benzoimidazoles from 1-Azido-2-isocyanoarenes.

       Dengke Li, Tingting Mao, Jinbo Huang and Qiang Zhu* Org. Lett., 2017, 19, 3223-3226. <Link>



54. Copper-catalyzed regioselective 1,2-thioamidation of alkenes.

       Dengke Li, Tingting Mao, Jinbo Huang and Qiang Zhu* Chem. Commun., 2017, 53, 3450-3453 . <Link>



53. Palladium-Catalyzed β-Selective C(sp2)−H Carboxamidation of Enamides by Isocyanide Insertion: Synthesis of N-Acyl Enamine Amides.

       Zhuang Xiong, Dongdong Liang* and Shuang Luo* Org. Chem. Front., 2017, 4, 1103-1106 . <Link>



52. A one-pot synthesis of [1,2,3]triazolo[1,5-a]quinoxalines from 1-azido-2-isocyanoarenes with high bond-forming efficiency.

      Dengke Li, Tingting Mao, Jinbo Huang* and Qiang Zhu* Chem. Commun., 2017, 53, 1305-1308. <Link>



2016     back to top



51. Pd-Catalyzed C(sp2)–H carbonylation of 2-benzylpyridines for the synthesis of pyridoisoquinolinones .

       Zeqiang Xie, Shuang Luo* and Qiang Zhu* Chem. Commun., 2016, 52, 12873-12876. <Link>


50. A metal-free synthesis of 2-aminobenzothiazoles through aminyl radical addition to aryl isothiocyanates.

       Yimiao He, Jing Li, Shuang Luo, Jinbo Huang* and Qiang Zhu* Chem. Commun., 2016, 52, 8444-8447. <Link>


49. Intramolecular Imidoylative Heck Reaction: Synthesis of Cyclic Ketoimines from Functionalized Isocyanide.

       Jian Wang, Shi Tang and Qiang Zhu* Org. Lett., 2016, 18, 3074-3077. <Link>


48. Copper-mediated C(sp3)–H azidation with Me3SiN3: synthesis of imidazoles from ketones and aldehydes .

       Zeqiang Xie, Jiaojiao Deng, Zhiping Qiu, Juan Li* and Qiang Zhu* Chem. Commun., 2016, 52, 6467-6470. <Link>


47. Transition Metal-Free Amidoalkylation of Benzothiazoles and Amidoalkylarylation of Activated Alkenes with N,N-Dialkylamides.

       Jian Wang, Jing Li,  Jinbo Huang* and Qiang Zhu* J. Org. Chem., 2016, 81, 3017-3022. <Link>


46. Recent progress in imidoyl radical-involved reactions.

        Jian Lei, Jinbo Huang and Qiang Zhu* Org. Biomol. Chem., 2016, 14, 2593-2602. <Link>


45. Dearomative C–C and C–N bond cleavage of 2-arylindoles: transition-metal-free access to 2-aminoarylphenones.

        Shuang Luo*, Ziwei Hu and Qiang Zhu* Org. Chem. Front., 2016, 3, 364-367. <Link>


44.  Copper-mediated C(sp3)–H amination in a multiple C–N bond-forming strategy for the synthesis of N-heterocycles.

        Zeqiang Xie, Jiangling Peng, and Qiang Zhu* Org. Chem. Front., 2016, 3, 82-86. <Link>



2015   back to top



43.  Copper-Promoted Cycloaddition of α-Methylenyl Isocyanides with Benzothiazoles: Tunable Access to Benzo[d]imidazothiazoles.

        Jian Wang, Jing Li, and Qiang Zhu* Org. Lett., 2015, 17, 5336–5339. <Link>



42.  Surface Confined Retro Diels–Alder Reaction Driven by the Swelling of Weak Polyelectrolytes.

        Beier Lyu, Wenli Cha, Tingting Mao, Yuanzi Wu, Hujun Qian, Yitian Zhou, Xiuli Chen, Shen Zhang, Lanying Liu, Guang Yang, Zhongyuan Lu, Qiang Zhu*, and Hongwei Ma* ACS Appl. Mater. Interfaces, 2015, 7, 62546259. <Link>


41. Copper-Catalyzed Trifluoromethylation of Trisubstituted Allylic and Homoallylic Alcohols.

        Jian Lei, Xiaowu Liu, Shaolin Zhang, Shuang Jiang, Minhao Huang, Xiaoxing Wu* and Qiang Zhu* Chem. Eur. J. 2015, 21 , 6700–6703. <Link>


40. Copper-Catalyzed Trifluoromethylalkynylation of Isocyanides.

       Jian Lei , Xiaoxing Wu * and Qiang Zhu * Org. Lett. 2015, 17 , 2322–2325. <Link>


39. Aminopalladation-Triggered Carbene Insertion Reaction: Synthesis of 2-(1H-Indol-3-yl)acetates.

       Ziwei Hu, Shuang Luo* and Qiang Zhu* Adv. Synth. Catal. 2015, 357, 1060–1064. <Link>


38. Palladium-catalyzed intermolecular C-H amidation of indoles with sulfonyl azides.

        Ziwei Hu, Shuang Luo*and Qiang Zhu* Sci. China. Chem. 2015, 58, 1349-1353. <Link>


37. Palladium-Catalyzed Intramolecular C(sp2)-H Imidoylation for the Synthesis of Six-Membered N-Heterocycles.

       Jing Li, Yimiao He, Shuang Luo, Jian Lei, Jian Wang, Zeqiang Xie, and Qiang Zhu* J. Org. Chem. 2015, 80, 2223–2230. <Link>


36. A Facile Synthesis of Pyrazoles through Metal-Free Oxidative C(sp2)[BOND]H Cycloamination of Vinyl Hydrazones.

       Dongdong Liang and Qiang Zhu* Asian J. Org. Chem. 2015, 4, 42-45. <Link>



2014   back to top


35. Cu/Fe-Cocatalyzed Meyer–Schuster-like Rearrangement of Propargylic Amines: Direct Access to E-β-Aminoacryaldehydes.

        Ming Chen, Jiangling Peng, Tingting Mao, and Jinbo Huang* Org. Lett. 2014, 16, 6286–6289. <Link>


34. A room-temperature synthesis of 2,2′-bisoxazoles through palladium-catalyzed oxidative coupling of α-isocyanoacetamides.

        Jian Wang, Shuang Luo, Jing Li and Qiang Zhu* Org. Chem. Front. 2014, 1, 1285-1288. <Link>


33. Copper-Catalyzed Intramolecular Oxidative C(sp3)–H Amidation of 2-Aminoacetophenones: Efficient Synthesis of Indoline-2,3-diones.

       Jinbo Huang,* Tingting Mao and Qiang Zhu* Eur. J. Org. Chem. 2014, 14, 2878–2882. <Link>



32. Copper-mediated C(sp2)–H amination using TMSN3 as a nitrogen source: redox-neutral access to primary anilines.

      Jiangling Peng, Ming Chen, Zeqiang Xie, Shuang Luo and Qiang Zhu* Org. Chem. Front. 2014, 1, 777-781. <Link>


31. Palladium-Catalyzed Imidoylative Cyclization of α-Isocyanoacetamides: Efficient Access to C2-Diversified Oxazoles.

    Jian Wang, Shuang Luo, Jinbo Huang, Tingting Mao and Qiang Zhu* Chem. Eur. J. 2014, 20, 11220–11224. <Link>


30. Palladium-Catalyzed C(sp2)–H Arylation Using Formamide as a Transformable Directing Group.

       Congqing Wan, Jiaji Zhao, Mingfang Xu*, and Jinbo Huang* J. Org. Chem. 2014, 79, 4751–4756. <Link>


29. Copper-Catalyzed C(sp2)–H Amidation with Azides as Amino Sources.

       Jiangling Peng, Zeqiang Xie, Ming Chen, Jian Wang, and Qiang Zhu* Org. Lett. 2014, 16, 4702–4705. <Link>


28. Palladium-Catalyzed C(sp2)–H Pyridocarbonylation of N-Aryl-2-aminopyridines: Dual Function of the Pyridyl Moiety.

       Dongdong Liang, Yimiao He, and Qiang Zhu* Org. Lett. 2014, 16, 2748–2751. <Link>


27. Arylative Cyclization of 2-Isocyanobiphenyls with Anilines: One-Pot Synthesis of 6-Arylphenanthridines via Competitive Reaction Pathways.

      Zhonghua Xia, Jinbo Huang, Yimiao He, Jiaji Zhao, Jian Lei, and Qiang Zhu* Org. Lett. 2014, 16, 2546–2549. <Link>



2013   back to top


26. Synthesis of phenanthridinones via palladium-catalyzed C(sp2)−H aminocarbonylation of unprotected o-arylanilines.

       Dongdong Liang, Ziwei Hu, Jiangling Peng, Jinbo Huang, and Qiang Zhu* Chem. Commun. 2013, 49, 173-175. <Link


25. Synthesis of 10-Methylacridin-9(10H)-ones through Cu-Catalyzed Intramolecular Oxidative C(sp2)−H Amination of o-N-methylaminobenzophenones.

      Jinbo Huang, Congqing Wan, Ming-Fang Xu,* and Qiang Zhu* Eur. J. Org. Chem. 2013, 1876-1880.  <Link>


24. C–H cycloamination of N-aryl-2-aminopyridines and N-arylamidines catalyzed by an in situ generated hypervalent iodine(III) reagent.

      Yimiao He, Jinbo Huang, Dongdong Liang, Lanying Liu and Qiang Zhu* Chem. Commun. 2013, 49, 7352-7354. <Link>


23. A Metal-Free Tandem Demethylenation/C(sp2) −H Cycloamination Process of N-Benzyl-2-aminopyridines via C- C and C- N Bond Cleavage.

      Dongdong Liang, Yimiao He, Lanying Liu, and Qiang Zhu* Org. Lett. 2013, 15, 3476-3479. <Link>


22. A Transition-Metal-Free Synthesis of Arylcarboxyamides from Aryl Diazonium Salts and Isocyanides.

      Zhonghua Xia and Qiang Zhu* Org. Lett. 2013, 15, 4110-4113.  <Link>


21. Synthesis of 1H-Indole-3-carboxamidines through a Palladium-Catalyzed Three-Component  Reaction Involving Isocyanide Insertion as a Key Step.

      Ziwei Hu, Jian Wang, Dongdong Liang, and Qiang Zhu* Adv. Synth. Catal. 2013, 355, 3290-3294.   <Link>



2012   back to top


20. Direct carboxamidation of indoles by palladium-catalyzed C−H activation and insertion.

      Jiangling Peng, Lanying Liu, Ziwei Hu, Jinbo Huang, Qiang Zhu*  Chem. Commun. 2012, 48, 3772-3774. <Link>


19. Cu-Catalyzed Oxidative C(sp2)−H Cycloetherification of o-Arylphenols for the Preparation of Dibenzofurans.

      Jiaji Zhao, Yong Wang, Yimiao He, Lanying Liu, Qiang Zhu* Org. Lett. 2012, 14, 1078-1081.  <Link>


18. Cu-Catalyzed Regioselective C−H Aerobic Oxidative Cycloetherification of o-Arylphenols Bearing an Additional Directing Group.

      Jiaji Zhao, Yong Wang, Qiang Zhu* Synthesis 2012, 44, 1551-1555.  <Link>


17.  Palladium(II)-Catalyzed Cycloamidination via C(sp2)-H Activation and Isocyanide Insertion.

    Yong Wang, Qiang Zhu* Adv. Synth. Catal. 2012, 354, 1902-1908. <Link>


16. Palladium-catalyzed cyclization of o-alkynyltrifluoroacetanilides followed by isocyanide insertion: synthesis of 2-substituted 1H-indole-3-carboxamides.     

     Ziwei Hu, Dongdong Liang, Jiaji Zhao, Jinbo Huang, and Qiang Zhu* Chem. Commun. 2012, 48, 7371-7373. <Link>


15. Palladium-Catalyzed C(sp2)−H Cyanation Using Tertiary Amine Derived Isocyanide as a Cyano Source.

     Jiangling Peng, Jiaji Zhao, Ziwei Hu, Dongdong Liang, Jinbo Huang, and Qiang Zhu* Org. Lett. 2012, 14, 4966-4969.  <Link>


14. CuI-Mediated Sequential Iodination/Cycloetherification of o-Arylphenols: Synthesis of 2- or 4-Iododibenzofurans and Mechanistic Studies.

      Jiaji Zhao, Qi Zhang, Lanying Liu, Yimiao He, Jing Li, Juan Li,* and Qiang Zhu* Org. Lett. 2012, 14, 5362-5365. <Link>


13. Synthesis of Benzimidazoles by PIDA-Promoted Direct C(sp2)−H Imidation of N-Arylamidines.

      Jinbo Huang, Yimiao He, Yong Wang, and Qiang Zhu* Chem. Eur. J. 2012, 18, 13964-13967.  <Link>



2011   back to top


12. Palladium-Catalyzed Intramolecular C(sp2)–H Amidination by Isonitrile Insertion Provides Direct Access to 4-Aminoquinazolines from N-Arylamidines.

     Yong Wang, Honggen Wang, Jiangling Peng, Qiang Zhu* Org. Lett. 2011, 13, 4604-4607. <Link>


11. Bronsted Acid-Promoted Sequential Hydroarylation-Hydroamidation of Arene Tethered 1-(2-Alkynylphenyl)ureas: Direct Access to 4,4-spiro-3,4-dihydro-2-(1H)-quinazolinones.

Honggen Wang, Jiaji Zhao, Jiancun Zhang*, Qiang Zhu* Adv. Synth. Catal. 2011, 2653-2658. <Link


10. Sequential Hydration–Condensation–Double Cyclization of Pyridine-Substituted 2-Alkynylanilines: An Efficient Approach to Quinoline-Based Heterocycles

       Lijie Peng, Honggen Wang, Changlan Peng, Ke Ding,* Qiang Zhu* Synthesis 2011, 1723-1732. <Link>


09. Synthesis of Quinazolin-4(3H)-ones via Pd(II)-Catalyzed Intramolecular C(sp2)−H Carboxamidation of N-arylamidines.

       Bin Ma, Yong Wang, Jiangling Peng, Qiang Zhu* J. Org. Chem. 2011, 76, 6362-6366. <Link


08. Copper-Catalyzed Intramolecular Dehydrogenative Aminooxygenation: Direct Access to Formyl-Substituted Aromatic N-Heterocycles.

      Honggen Wang, Yong Wang, Dongdong Liang, Lanying Liu, Jiancun Zhang,* Qiang Zhu* Angew. Chem., Int. Ed. 2011, 50, 5678-5681. <Link>



2010   back to top


07. Synthesis of 2-Alkoxy(aroxy)-3-substituted Quinolines by DABCO-Promoted Cyclization of ortho-Alkynylaryl Isocyanides.

       Jiaji Zhao, Changlan Peng, Lanying Liu, Yong Wang, Qiang Zhu* J. Org. Chem. 2010, 75, 7502-7504. <Link>


06. A Direct Intramolecular C−H Amination Reaction Co-Catalyzed by Copper(II) and Iron(III) as Part of an Efficient Route for the Synthesis of Pyrido[1,2-a]benzimidazoles from N-Aryl-2-aminopyridines. 

   Honggen Wang, Yong Wang, Changlan Peng, Jiancun Zhang*, Qiang Zhu* J. Am. Chem. Soc. 2010, 132, 13217-13219. <Link>


05. p-Toluenesulfonic Acid Promoted Annulation of 2-Alkynylanilines with Activated Ketones: Efficient Synthesis of 4-Alkyl-2,3-Disubstituted Quinolines.

      Changlan Peng, Yong Wang, Lanying Liu, Honggen Wang, Jiaji Zhao, Qiang Zhu* Eur. J. Org. Chem. 2010, 818-822. <Link>


04. Structure-based design, synthesis and biological evaluation of new N-carboxyphenylpyrrole derivatives as HIV fusion inhibitors targeting gp41.

       Yong Wang, Hong Lu, Qiang Zhu*, Shibo Jiang*, Yun Liao* Bioorg. Med. Chem. Lett. 2010, 20, 189-192. <Link>



2009   back to top


03. An efficient synthesis of 4-alkyl-2(1H)-quinazolinones and 4-alkyl-2-chloroquinazolines from 1-(2-alkynylphenyl)ureas.

       Honggen Wang, Lanying Liu, Yong Wang, Changlan Peng, Jiancun Zhang*, Qiang Zhu* Tetrahedron Lett. 2009, 50, 6841-6843. <Link>


02. Tetrabutylammonium chloride-triggered 6-endo cyclization of o-alkynylisocyanobenzenes: an efficient synthesis of 2-chloro-3-substituted quinolines.

      Lanying Liu, Yong Wang, Honggen Wang, Changlan Peng, Jiaji Zhao, Qiang Zhu* Tetrahedron Lett. 2009, 50, 6715-6719.  <Link>


01. Sulfuric acid promoted condensation cyclization of 2-(2-(trimethylsilyl)ethynyl)anilines with arylaldehydes in alcoholic solvents: an efficient one-pot synthesis of 4-alkoxy-2-arylquinolines. 

Yong Wang, Changlan Peng, Lanying Liu, Jiaji Zhao, Li Su, Qiang Zhu* Tetrahedron Lett. 2009, 50, 2261-2265. <Link>